Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats.

@article{Kihara2001RoleOT,
  title={Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats.},
  author={Yasuyuki Kihara and Mitsuo Tashiro and Hayato Nakamura and Taizo Yamaguchi and Hiroyuki Yoshikawa and Makoto Otsuki},
  journal={Pancreas},
  year={2001},
  volume={23 3},
  pages={288-95}
}
INTRODUCTION Pancreatic tissues are almost completely restored to normal after an attack of acute pancreatitis, once the cause of the disease is removed. Transforming growth factor (TGF)-beta and extracellular matrix (ECM) are known to play an important role in the process of wound healing in pathologic diseases. Tissue repair is a process regulated by a balance between synthesis and degradation of ECM. AIMS To elucidate the role of TGF-beta, ECM, and matrix metalloproteinase (MMP) in the… CONTINUE READING