Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod.

@article{Gaan1996RoleOT,
  title={Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod.},
  author={Yolanda Ga{\~n}an and Domingo Mac{\'i}as and Martine Duterque-Coquillaud and Marian A Ros and Juan M Hurle},
  journal={Development},
  year={1996},
  volume={122 8},
  pages={2349-57}
}
The establishment of the digital rays and the interdigital spaces in the developing limb autopod is accompanied by the occurrence of corresponding domains of expression of TGF beta s and BMPs. This study analyzes whether these coincident events are functionally correlated. The experiments consisted of local administration of TGF beta-1, TGF beta-2 or BMP-4 by means of heparin or Affi-gel blue beads to the chick limb autopod in the stages preceding the onset of interdigital cell death. When… CONTINUE READING
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