Role of TGF-β in melanoma.

  title={Role of TGF-β in melanoma.},
  author={Antonia Busse and Ulrich Keilholz},
  journal={Current pharmaceutical biotechnology},
  volume={12 12},
Human malignant melanoma is highly resistant to chemotherapy and current immunotherapeutic approaches induce long term remission only in the minority of patients. The transforming growth factor-β (TGF-β) has attracted much attention as a therapeutic target because it plays an important and pleiotropic role in melanoma progression. TGF-β is a multifunctional cytokine involved in the regulation of many cellular processes including cell proliferation, differentiation and survival. Resistance to… CONTINUE READING
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