Role of TGF-β and the tumor microenvironment during mammary tumorigenesis.

@article{Taylor2011RoleOT,
  title={Role of TGF-β and the tumor microenvironment during mammary tumorigenesis.},
  author={Molly A Taylor and Yong-Hun Lee and William P. Schiemann},
  journal={Gene expression},
  year={2011},
  volume={15 3},
  pages={117-32}
}
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that functions to inhibit mammary tumorigenesis by directly inducing mammary epithelial cells (MECs) to undergo cell cycle arrest or apoptosis, and to secrete a variety of cytokines, growth factors, and extracellular matrix proteins that maintain cell and tissue homeostasis. Genetic and epigenetic events that transpire during mammary tumorigenesis typically inactivate the tumor suppressing activities of TGF-beta and… CONTINUE READING