Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling

@article{Liu2019RoleOT,
  title={Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling},
  author={Bo Liu and Damin Wang and Erfei Luo and Jiantong Hou and Yong Qiao and Gaoliang Yan and Qingjie Wang and Chengchun Tang},
  journal={Frontiers in Pharmacology},
  year={2019},
  volume={10}
}
Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up Ca2+ from the cytoplasm to maintain the balance of intracellular Ca2+. A decline in expression or activity of SERCA results in persistent store-operated calcium entry (SOCE). In cardiomyocytes as well as vascular smooth muscle cells (SMCs), SERCA2 acts as an important regulator of calcium cycling. The purpose of this study is to identify and better understand the role of transglutaminases2 (TG2) as a key factor involved in SERCA2… Expand
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