Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling

  title={Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling},
  author={Bo Liu and Damin Wang and Erfei Luo and Jiantong Hou and Yong Qiao and Gaoliang Yan and Qingjie Wang and Chengchun Tang},
  journal={Frontiers in Pharmacology},
Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up Ca2+ from the cytoplasm to maintain the balance of intracellular Ca2+. A decline in expression or activity of SERCA results in persistent store-operated calcium entry (SOCE). In cardiomyocytes as well as vascular smooth muscle cells (SMCs), SERCA2 acts as an important regulator of calcium cycling. The purpose of this study is to identify and better understand the role of transglutaminases2 (TG2) as a key factor involved in SERCA2… Expand
5 Citations
Hypoxia-induced PINK1/Parkin-mediated mitophagy promotes pulmonary vascular remodeling.
Results suggest that hypoxia can activate the PINK1/Parkin-mediated mitophagy pathway, induce the excessive proliferation of PASMCs, eventually lead to PVR, leading to HPH. Expand
Over Expressed lncRNA AC068039.4 Contributes to Proliferation and Cell Cycle Progression of Pulmonary Artery Smooth Muscle Cells Via Sponging miR-26a-5p/TRPC6 in Hypoxic Pulmonary Arterial Hypertension.
Downregulation of lncRNAs inhibited pulmonary vascular remodeling through AC068039.4/miR-26a-5p/TRPC6 axis, providing new therapeutic insights for the treatment of HPH. Expand
The physiology, pathology and potential therapeutic application of serotonylation.
This Review highlights the roles of serotonylation in physiology and diseases and provides perspectives for pharmacological interventions to ameliorate serotoneylation for disease treatment. Expand
Cross-Talk between Mechanosensitive Ion Channels and Calcium Regulatory Proteins in Cardiovascular Health and Disease
  • Yaping Wang, Jian Shi, Xiaoyong Tong
  • Medicine
  • International journal of molecular sciences
  • 2021
The cross-talk between mechanosensitive ion channels and some key Ca2+ regulatory proteins in the maintenance of calcium homeostasis is reviewed and its relevance to cardiovascular health and disease is reviewed. Expand
Tsantan Sumtang Restored Right Ventricular Function in Chronic Hypoxia-Induced Pulmonary Hypertension Rats
Tsantan Sumtang was able to restore RV function, improve RV-PA coupling, recover hemodynamic and hematological indexes, and protect RV against structural maladaptive remodeling in the HPH rats. Expand


SUMO1-dependent modulation of SERCA2a in heart failure
The data show that SUMOylation is a critical post-translational modification that regulates SERCA2a function, and provide a platform for the design of novel therapeutic strategies for heart failure. Expand
Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
An important role for TG2, mediated by intracellular calcium fluxes and HIF-1α, in hypoxia-induced PASMC proliferation and possibly in vascular remodeling in PH is suggested. Expand
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases
The mechanism of Ca2+ regulation by SERCA2a is described, the beneficial effects as well as the failures, risks and complexities associated with SER CA2a overexpression are examined, and the potential of SERCA 2a as a target for the treatment of cardiovascular disease is discussed. Expand
Chronic Hypoxia Increases TRPC6 Expression and Basal Intracellular Ca2+ Concentration in Rat Distal Pulmonary Venous Smooth Muscle
Hypoxia induces elevation of SOCE in distal PVSMCs, leading to enhancement of basal [Ca2+]i in PVS MCs, which is potentially correlated with the increased expression of TRPC6. Expand
Upregulation of Nox4 by TGF&bgr;1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat
It is indicated that the upregulation of Nox4 by transforming growth factor-&bgr;1 in ZO SMCs is responsible for the impaired response to NO by a mechanism involving the oxidation of SERCA C674. Expand
Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells.
These findings, together with previous observations that FN expression in the lung strongly correlates with the progression of pulmonary hypertension in both experimental animals and humans, suggest an important role of FN serotonylation in the pathogenesis of this disease. Expand
Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.
This review aims to give an overview of the vast literature concerning the cell biological implications of the SERCA2 isoform diversity and the factors regulatingSERCA2. Expand
Transglutaminase 2-mediated serotonylation in pulmonary hypertension.
  • K. Penumatsa, B. Fanburg
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
  • 2014
The present review has tried to address the current understanding of 5-HT metabolism in pulmonary hypertension and relate it to what is currently known about the evolving cellular process of serotonylation. Expand
Impact of S-Adenosylmethionine Decarboxylase 1 on Pulmonary Vascular Remodeling
This study indicates that genome-wide screening in mice from a PH model in which full reversal of PH occurs can be useful to identify potential key candidates for the reversal and development of PH. Expand
Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
TG2 contributes to 5-HT-induced distal PASMC proliferation via promotion of AKT signaling, likely via its serotonylation, which provides new insight into how TG2 may participate in vascular smooth muscle remodeling. Expand