Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis

@article{Li2018RoleOT,
  title={Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis},
  author={Zhengqiang Li and Zhimin Xu and Congcong Duan and Weiwei Liu and Jingchun Sun and Bing Han},
  journal={International Journal of Medical Sciences},
  year={2018},
  volume={15},
  pages={1415 - 1422}
}
Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and endochondral ossification. In both mechanisms, osteoblasts play an important role in the secretion and mineralization of bone-specific extracellular matrix. Differentiation and maturation of osteoblasts is a prerequisite to bone formation and is regulated by many factors. Recent experiments have shown that transcription factors play an important role in regulating osteoblast differentiation, proliferation, and… Expand
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