Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae.

@article{Feng1997RoleOT,
  title={Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae.},
  author={Hui-min Feng and Vsevolod L. Popov and G. Yuoh and David H Walker},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5314-20}
}
To evaluate the roles of CD4 and CD8 T lymphocytes in immunity to disseminated endothelial infection with Rickettsia conorii (Malish 7 strain), these T cell subsets were depleted or adoptively transferred into subsequently infected C3H/HeN mice. CD4 T lymphocyte-depleted and sham-depleted mice underwent a similar course of illness with a sublethal rickettsial dose, cleared the infection by day 10, and recovered on days 10 to 11. In contrast, mice depleted of CD8 lymphocytes or CD4 and CD8… CONTINUE READING
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