Role of T cells and germinal center formation in the generation of immune responses to the thymus-independent carbohydrate dextran B512.

@article{Sverremark1998RoleOT,
  title={Role of T cells and germinal center formation in the generation of immune responses to the thymus-independent carbohydrate dextran B512.},
  author={Eva Sverremark and Carmen Fern{\'a}ndez},
  journal={Journal of immunology},
  year={1998},
  volume={161 9},
  pages={4646-51}
}
Immunization with the thymus-independent (TI) Ag native dextran (DX) B512 induces germinal center (GC) formation in the spleen. However, despite this GC formation, the anti-DX response is poor, and no affinity maturation can be observed. Using cholera toxin (CT) as an adjuvant, splenic as well as humoral responses to DX are improved. In this study, we investigated immune responses against DX in mice lacking TNF receptor I and in athymic mice. The adjuvant effect of CT on these responses was… CONTINUE READING

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