Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.

@article{Sher1992RoleOT,
  title={Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.},
  author={Alan Sher and Ricardo Tostes Gazzinelli and Isabelle P Oswald and Mario Clerici and Marika C. Kullberg and Edward J. Pearce and Jay A. Berzofsky and Tim R. Mosmann and Sheronica L James and Herbert C. Morse},
  journal={Immunological reviews},
  year={1992},
  volume={127},
  pages={183-204}
}
Parasitic infection is frequently accompanied by a downregulation in host cell-mediated immunity. Recent studies suggest that this modulation of helper T cells and effector cell function can at least in part be attributed to the action of a set of inhibitory cytokines produced by T lymphocytes as well as by a number of other cell types. The best characterized of these inhibitory lymphokines are IL-4, IL-10 and TGF-beta. Interestingly, both IL-4 and IL-10 are produced by the Th2 but not the Th1… CONTINUE READING

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