Role of T-cell-associated lymphocyte function-associated antigen-1 in the pathogenesis of experimental colitis.

@article{Pavlick2006RoleOT,
  title={Role of T-cell-associated lymphocyte function-associated antigen-1 in the pathogenesis of experimental colitis.},
  author={Kevin P. Pavlick and Dmitry V. Ostanin and Kathryn L. Furr and F. Stephen Laroux and Carla M Brown and Laura Gray and Christopher G. Kevil and Matthew B Grisham},
  journal={International immunology},
  year={2006},
  volume={18 2},
  pages={389-98}
}
The beta2 integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) is important for lymphocyte trafficking and activation as well as recruitment to sites of tissue inflammation. The objective of this study was to assess the role of 'T-cell-associated' LFA-1 in the pathogenesis of chronic colitis in vivo. Transfer of CD4+CD25- T cells isolated from wild-type (wt) mice into immunodeficient recipients [recombinase-activating gene-1-deficient (RAG-1-/-] produced moderate to severe… CONTINUE READING

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