Role of Sustained Overexpression of Central Nervous System IGF-I in the Age-Dependent Decline of Mouse Excitation-Contraction Coupling

@article{Moreno2006RoleOS,
  title={Role of Sustained Overexpression of Central Nervous System IGF-I in the Age-Dependent Decline of Mouse Excitation-Contraction Coupling},
  author={Ram{\'o}n Antonio Jim{\'e}nez Moreno and Mar{\'i}a Laura Messi and Zhenlin Zheng and Zhong-Min Wang and Ping Ye and Joseph A. D'Ercole and Osvaldo Delbono},
  journal={The Journal of Membrane Biology},
  year={2006},
  volume={212},
  pages={147-161}
}
We investigated the effects of exclusive and sustained transgenic overexpression of insulin-like growth factor (IGF)-I in the central nervous system (CNS) on the age-dependent decline in muscle strength, excitation-contraction coupling, muscle innervation and neuromuscular junction postterminal architecture. We found that (1) transgenic IGF-I overexpression in the CNS does not modify the decline in extensor digitorum longus (EDL) and soleus muscle weight with aging and (2) strength… Expand
The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS
TLDR
Investigation of the effect of specific and sustained IGF-1 expression in skeletal muscle or central nervous system on motor performance, life span, and motor neuron survival in the spinal cord of human-IGF-1 transgenic mice found no significant differences, which raises questions concerning the therapeutic value of IGF- 1. Expand
Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle
TLDR
This chapter focuses on skeletal muscle excitation-contraction uncoupling (ECU), external calcium-dependent skeletal muscle contraction, the role of JP-45 and other recently discovered molecules of the muscle T-tubule-sarcoplasmic reticulum junction (triad), the neural influence of skeletal muscle, and the roles of trophic factors–particularly insulin-like growth factor-I (IGF-1). Expand
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice
TLDR
Important sex differences in how brain IGF-1 action impacts healthspan are highlighted and suggest that translational approaches that target IGF- 1 centrally can restore cognitive function, a possibility that should be explored as a strategy to combat age-related cognitive decline. Expand
Increased CaVβ1a expression with aging contributes to skeletal muscle weakness
TLDR
These studies imply CaVβ1a serves as both a positive and negative regulator CaV1.1 expression, and that endogenous overexpression of CaV β1a during old age may play a role in the loss of specific force. Expand
Insulin‐like growth factor‐I E peptides: implications for ageing skeletal muscle
In skeletal muscle there is good evidence to suggest that locally produced insulin‐like growth factor‐1 (IGF‐I), rather than circulating IGF‐I, is important in regard to muscle mass maintenance,Expand
Age Related Changes in Motor Function (II). Decline in Motor Performance Outcomes.
TLDR
In this second part of a two-part review, the age-related impairments in motor performance is detailed with a reference to the most important mechanical and neuromuscular contributing factors. Expand
Evolving concepts on the age-related changes in “muscle quality”
TLDR
The age-associated changes in the neuromuscular system—starting at the level of the brain and proceeding down to the subcellular level of individual muscle fibers—that are potentially influential in the etiology of dynapenia (age-related loss of muscle strength and power) are discussed. Expand
Altered Ca2+ sparks in aging skeletal and cardiac muscle
TLDR
The contribution of age-related modification of the Ca2+ release machinery and the effect of membrane structure and membrane cross-talk on the alteredCa2+ spark signaling during aging of striated muscles are highlighted. Expand
Peripheral Nerve Decline Impacts Lower Extremity Muscle Function in Older Adults
TLDR
Findings from the Health Aging and Body Composition Study indicate that sensory and motor nerve function are predictive of subsequent strength and concurrent change in strength, although improvement in nerve function may not always lead to improvements in strength. Expand
Skeletal muscle performance and ageing
TLDR
A broad overview on the underlying mechanisms associated with elderly skeletal muscle performance is provided and major implications for scientists, clinicians, and health professionals who are developing therapeutic interventions aiming to enhance muscle function and/or prevent mobility and physical limitations are developed. Expand
...
1
2
...

References

SHOWING 1-10 OF 74 REFERENCES
Target-Derived Trophic Effect on Skeletal Muscle Innervation in Senescent Mice
TLDR
Analysis of the nerve terminal in extensor digitorum longus muscles from senescent mice showed that the decrease in the percentage of cholinesterase-stained zones (CSZ) exhibiting nerve terminal branching, number of nerve branches at the CSZ, and nerve branch points was partially or completely reversed by sustained overexpression of IGF-1 in skeletal muscle. Expand
Sustained overexpression of IGF-1 prevents age-dependent decrease in charge movement and intracellular Ca(2+) in mouse skeletal muscle.
TLDR
The concept that overexpression of IGF-1 in skeletal muscle prevents age-dependent reduction in charge movement and peak intracellular calcium [Ca(2+)](i) is supported. Expand
Overexpression of IGF-1 Exclusively in Skeletal Muscle Prevents Age-related Decline in the Number of Dihydropyridine Receptors*
TLDR
The concept that IGF-1- dependent prevention of age-related decline in DHPR expression is associated with stronger muscle contraction in older transgenic mice is supported. Expand
Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.
TLDR
The results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated. Expand
Mutant mouse models of insulin-like growth factor actions in the central nervous system
TLDR
A role for IGF-I in neural development is confirmed, and experiments in mutant mice indicate that IGF- I stimulates neurogenesis and synaptogenesis, facilitates oligodendrocyte development, promotes neuron and oligod endocrine survival, and stimulates myelination. Expand
Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
TLDR
It is suggested that muscle fibers provide appropriate factors, such as mIgf-1, for neuron survival and muscle-restricted expression of a localized insulin-like growth factor maintained muscle integrity and enhanced satellite cell activity in SOD1G93A transgenic mice, inducing calcineurin-mediated regenerative pathways. Expand
Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
TLDR
A model of persistent, functional myocyte hypertrophy is generated using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1) and suggests clinical strategies for the treatment of age or disease-related muscle frailty. Expand
Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice
TLDR
It is found that myelin staining, MBP and PLP expression, and the percentage of oligodendrocytes and their precursors are significantly reduced in all brain regions of developing IGF-I KO mice but are similar to controls in adult IGF-i KO mice, suggesting that IGF-II can compensate in part for IGF- I actions on myelination. Expand
Insulin‐like growth factor‐1 prevents age‐related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice
In the present work we test the hypothesis that sustained transgenic overexpression of insulin‐like growth factor‐1 (IGF‐1) in skeletal muscle prevents age‐related decreases in myoplasmic Ca2+Expand
Neural control of aging skeletal muscle
TLDR
The present article discusses the evidence for neural influence on age‐related impairments of skeletal muscle, including a role in excitation–contraction uncoupling, and the role of nerves in regulating the trophic actions of insulin‐like growth factor‐1 and other neurotrophic factors is considered as a novel influence on the effects of aging on the neuromuscular junction. Expand
...
1
2
3
4
5
...