Role of Survival Motor Neuron Complex Components in Small Nuclear Ribonucleoprotein Assembly*

  title={Role of Survival Motor Neuron Complex Components in Small Nuclear Ribonucleoprotein Assembly*},
  author={Chihiro Ogawa and Kengo Usui and Fuyu Ito and Masayoshi Itoh and Yoshihide Hayashizaki and Harukazu Suzuki},
  journal={Journal of Biological Chemistry},
  pages={14609 - 14617}
Survival motor neuron (SMN) complex is essential for the biogenesis of the small nuclear ribonucleoprotein (snRNP) complex, although the complete role of each SMN complex component for the snRNP synthesis is largely unclear. We have identified an interaction between the two components Gemin2-Gemin7 using the mammalian two-hybrid system. In vitro stability assay revealed that the known SMN-Gemin7 interaction becomes stable in the presence of Gemin2 possibly via the identified Gemin2-Gemin7… 

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