Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.

  title={Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.},
  author={Alessandro Protti and Tommaso Maraffi and Marta Milesi and Emiliano Votta and Alessandro Santini and Paola Pugni and Davide Tommaso Andreis and Francesco Nicosia and Emanuela Zannin and Stefano Gatti and Valentina Vaira and Stefano Ferrero and Luciano Gattinoni},
  journal={Critical care medicine},
  volume={44 9},
OBJECTIVE Lungs behave as viscoelastic polymers. Harms of mechanical ventilation could then depend on not only amplitude (strain) but also velocity (strain rate) of lung deformation. Herein, we tested this hypothesis. DESIGN Laboratory investigation. SETTING Animal unit. SUBJECTS Thirty healthy piglets. INTERVENTIONS Two groups of animals were ventilated for 54 hours with matched lung strains (ratio between tidal volume and functional residual capacity) but different lung strain rates… CONTINUE READING
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