Role of Src homology 2 domain-mediated PTK signaling in mouse zygotic development.

  title={Role of Src homology 2 domain-mediated PTK signaling in mouse zygotic development.},
  author={Li Meng and Jinping Luo and C Li and William H Kinsey},
  volume={132 3},
Fyn and other Src-family kinases play an essential role at several steps during egg activation following fertilization of externally fertilizing species, such as marine invertebrates, fish, and frogs. Recent studies demonstrate that the requirement for Src-family kinases in activation of the mammalian egg is different from lower species, and the objective of this study was to test the role of the Fyn kinase in the mouse egg activated by intracytoplasmic sperm injection (ICSI). An Src homology 2… CONTINUE READING


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