Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.

@article{Bombail2004RoleOS,
  title={Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.},
  author={Vincent Bombail and Kevin Taylor and Gordon G. Gibson and Nick D Plant},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 5},
  pages={
          525-35
        }
}
Cytochrome P450 3A4 (CYP3A4) is the major cytochrome P450 present in adult human liver and is involved in the metabolism of over 50% of therapeutic compounds currently in use. Since expression levels of CYP3A4 are regulated by many of these compounds, this raises the potential for drug-drug interactions and subsequent altered efficacy or toxicity of the individual compounds at the dose prescribed. Hence, understanding the molecular mechanisms of CYP3A4 regulation is of key importance in… CONTINUE READING
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Pharmacogenetics/genomics and personalized medicine.

  • Human molecular genetics
  • 2005
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