Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung.

Abstract

Sonic hedgehog (Shh) was conditionally deleted in respiratory epithelial cells of the embryonic lung in vivo. Deletion of Shh before embryonic day (E) 13.5 resulted in respiratory failure at birth. While lobulation was not perturbed, the lungs were hypoplastic, with reduced branching of peripheral lung tubules, evident from E13.5. Smooth muscle and… (More)

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@article{Miller2004RoleOS, title={Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung.}, author={Leigh-Anne D Miller and Susan E. Wert and Jean C. Clark and Yan Xu and Anne Karina Perl and Jeffrey A. Whitsett}, journal={Developmental dynamics : an official publication of the American Association of Anatomists}, year={2004}, volume={231 1}, pages={57-71} }