Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker.

@article{Abe2011RoleOS,
  title={Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker.},
  author={Hideharu Abe and Takeshi Matsubara and Hidenori Arai and Toshio Doi},
  journal={Histology and histopathology},
  year={2011},
  volume={26 4},
  pages={531-41}
}
Diabetic nephropathy (DN) is the leading cause of chronic kidney failure. Moreover, DN is associated with elevated cardiovascular morbidity and mortality. DN is characterized by progressive expansion of the mesangial matrix and thickening of the glomerular basement membrane, resulting in the obliteration of glomerular capillaries. Advanced glycation endproducts (AGEs) produced as the result of hyperglycemia are known to stimulate the production of extracellular matrix (ECM) proteins, resulting… CONTINUE READING