Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor.

@article{Basu1994RoleOS,
  title={Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor.},
  author={Tapan Basu and Patricia H. Warne and Julian Downward},
  journal={Oncogene},
  year={1994},
  volume={9 12},
  pages={3483-91}
}
Treatment of the rat pheochromocytoma cell line PC12 with nerve growth factor (NGF) or epidermal growth factor (EGF) is known to result in activation of Ras. In response to EGF treatment, complexes form between Sos, Grb2 and tyrosine phosphorylated Shc and/or EGF receptor. In response to NGF treatment, complexes form between Sos, Grb2 and tyrosine phosphorylated Shc. While Shc is also found bound to the activated NGF receptor, Trk, no complexes were detectable that contained both Trk and Grb2… CONTINUE READING