Role of Serotonin via 5-HT2B Receptors in the Reinforcing Effects of MDMA in Mice

@inproceedings{Doly2009RoleOS,
  title={Role of Serotonin via 5-HT2B Receptors in the Reinforcing Effects of MDMA in Mice},
  author={St{\'e}phane Doly and Jesus Bertran-Gonzalez and Jacques Callebert and Alexandra Bruneau and Sophie Marie Banas and Arnauld Belmer and Katia Boutourlinsky and Denis Herv{\'e} and J. -F. Launay and Luc Maroteaux},
  booktitle={PloS one},
  year={2009}
}
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the role of serotonin/dopamine interactions in the behavioral effects of MDMA remains unclear. We previously showed that MDMA-induced locomotion, serotonin and dopamine release are 5-HT(2B) receptor-dependent. The aim of the present study was to… CONTINUE READING

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