Role of Serotonin in Depression a

  title={Role of Serotonin in Depression a},
  author={Herbert Y. Meltzer},
  journal={Annals of the New York Academy of Sciences},
  • H. Meltzer
  • Published 1 October 1990
  • Psychology
  • Annals of the New York Academy of Sciences
There is extensive evidence that serotonin (5-HT) may play an important role in making persons vulnerable to depression or mania, in the precipitation of an episode of depression or mania, or in the mechanism of action of drugs which have an antidepressant, antimanic or mood stabilizing effect.’.’Some of the evidence for these conclusions will be critically reviewed and some new data from our laboratory will be presented. 

Serotonin and alcohol intake, abuse, and dependence: Clinical evidence

Decreased 5-HT-Mediated Prolactin Release in Major Depression

Findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5- HT function rather than a pituitary abnormality.

Evaluating The Antidepressant Efficacy of Aripiprazole Using a Chronic Mild Stress Model: An Experimental Study

Evaluating the antidepressant potential of aripiprazole in rats by studying its effects on dopamine and serotonin receptors and partial D2 receptor agonism.

Mechanism of acute tryptophan depletion: is it only serotonin?

It is suggested that caution is required when interpreting ATD effects in terms of a selective serotonergic effect, as the potential of alternative mechanisms and possible confounding factors should be taken into account.

The Role of Central Serotonergic Dysfunction in the Aetiology of Premenstrual Dysphoric Disorder

  • B. Parry
  • Psychology, Biology
    CNS drugs
  • 2001
Most of the evidence from baseline studies suggests predominantly a serotonergic rather than a noradrenergic or dopaminergic dysfunction in PMDD, which is more consistent than those of other neuroendocrine abnormalities for example.

Psychoneuroendocrinology of depression. Prolactin.

The Clinical Pharmacology and Use of Paroxetine, a New Selective Serotonin Reuptake Inhibitor

Paroxetine in dosages of 20–50 mg/day is as effective as the older classic antidepressants, including amitriptyline, imipramine, and doxepin, and in patients with recurrent, resistant, or severe depression.

Fluoxetine and Suicidal Behaviour

Since a report by Teicher et al (1990) of suicidal preoccupation associated with fluoxetine treatment, there has been both intense media interest and animated correspondence in clinical and scientific journals.



A Biochemical and Neuroendocrine Study of the Serotonergic System in Depression

The evidence for the role of 5- HT in depression is not yet conclusive, and additional data are needed to clarify the nature of the defect and to identify those depressed patients for whom brain 5-HT deficiences are most critical.

5‐HT reuptake inhibitors plus tryptophan in endogenous depression

Patients in the latter group showed a significantly more rapid improvement than those in the former group, especially with regard to the depression‐anxiety cluster of symptoms.

L-tryptophan in mania. Contribution to a permissive hypothesis of affective disorders.

Five manic patients were treated with chlorpromazine hydrochloride (CPZ), then with L-tryptophan (LTP), and five with LTP first, then CPZ, in a double-blind, placebo-controlled crossover study. LTP

Potentiation of a monoamine oxidase inhibitor by tryptophan.

Serotonin uptake in blood platelets of psychiatric patients.

Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients and there was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement.

Platelet 3H-paroxetine binding in depressed patients

Double‐blind comparison between a serotonin and a noradrenaline reuptake blocker in the treatment of depressed outpatients

Good response to the NA drug correlated to few prior episodes and few years since first episode, whereas the 5‐HT drug had its best effect when there were several previous episodes.

Influence of unilateral ECT on tryptophan metabolism in endogenous depression.

The results are consistent with the notion of disturbances in tryptophan metabolism in patients with endogenous depression, but they fail to clarify the mechanism responsible for the antidepressant effect of ECT.

Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects.

There was a marked blunting of the maximal prolactin response to the tryptophan in both the male and female patients, providing strong support for a possible serotonergic abnormality in depression.