Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)

@inproceedings{Rosado2012RoleOS,
  title={Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)},
  author={Leonardo Astolfi Rosado and Rafael A. Caceres and Walter Filgueira de Azevedo and Luiz Augusto Basso and Di{\'o}genes Santiago Santos},
  booktitle={BMC Research Notes},
  year={2012}
}
Tuberculosis (TB) still remains one of the most deadly infectious diseases in the world. Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA) is a member of the fatty acid elongation system type II, providing precursors of mycolic acids that are essential to the bacterial cell growth and survival. MabA has been shown to be essential for M. tuberculosis survival and to play a role in intracellular signal transduction of bacilli. Here we describe site-directed mutagenesis, recombinant… CONTINUE READING
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