Role of SUMO in the dynamics of telomere maintenance in fission yeast.

@article{Xhemalce2007RoleOS,
  title={Role of SUMO in the dynamics of telomere maintenance in fission yeast.},
  author={Blerta Xhemalce and Eva Madi Riising and Peter Baumann and Anne Dejean and Benoit Arcangioli and J Seeler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 3},
  pages={893-8}
}
The sheltering of chromosome ends from illegitimate DNA repair reactions and telomere length homeostasis are critical for preserving genomic integrity. Growing evidence implicates covalent protein modification by SUMO (small ubiquitin-like modifier) (sumoylation) in the regulation of numerous DNA transactions, including DNA repair and transcription, as well as heterochromatin formation and maintenance. We have recently shown that fission yeast Pli1p is a SUMO E3 ligase and that pli1 mutants… CONTINUE READING