Role of SUMO-1-modified PML in nuclear body formation.

  title={Role of SUMO-1-modified PML in nuclear body formation.},
  author={Sue Zhong and Stefan M{\"u}ller and Simona Ronchetti and Paul S. Freemont and Anne Dejean and Pier Paolo Pandolfi},
  volume={95 9},
The tumor-suppressive promyelocytic leukemia (PML) protein of acute promyelocytic leukemia (APL) has served as one of the defining components of a class of distinctive nuclear bodies (NBs). PML is delocalized from NBs in APL cells and is degraded in cells infected by several viruses. In these cells, NBs are disrupted, leading to the aberrant localization of NB proteins. These results have suggested a critical role for the NB in immune response and tumor suppression and raised the question of… CONTINUE READING