Role of STAT3 in skin fibrosis and transforming growth factor beta signalling.

@article{Pedroza2018RoleOS,
  title={Role of STAT3 in skin fibrosis and transforming growth factor beta signalling.},
  author={M. R. Ortiz Pedroza and Sarah To and Shervin Assassi and Minghua Wu and David J Tweardy and Sandeep K Agarwal},
  journal={Rheumatology},
  year={2018},
  volume={57 10},
  pages={
          1838-1850
        }
}
Objective SSc is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. IL-6 and related cytokines that signal through STAT3 have been implicated in the pathogenesis of SSc and mouse models of fibrosis. The aim of this study was to investigate the efficacy of inhibiting STAT3 in the development of fibrosis in two mouse models of skin fibrosis. Methods Biopsy samples of skin from SSc patients and healthy control subjects were used to determine the… CONTINUE READING
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