Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA

Abstract

β-lactam antibiotics target penicillin-binding proteins (PBPs) preventing peptidoglycan synthesis and this inhibition is circumvented in methicillin resistant Staphylococcus aureus (MRSA) strains through the expression of an additional PBP, named PBP2A. This enzyme is encoded by the mecA gene located within the Staphylococcal Chromosome Cassette mec (SCCmec… (More)
DOI: 10.1038/s41598-017-06329-2

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