Role of S6 phosphorylation and S6 kinase in cell growth.

  title={Role of S6 phosphorylation and S6 kinase in cell growth.},
  author={Sini{\vs}a Volarevi{\'c} and George Thomas},
  journal={Progress in nucleic acid research and molecular biology},
This article reviews our current knowledge of the role of ribosomal protein S6 phosphorylation and the S6 kinase (S6K) signaling pathway in the regulation of cell growth and proliferation. Although 40S ribosomal protein S6 phosphorylation was first described 25 years ago, it only recently has been implicated in the translational up-regulation of mRNAs coding for the components of protein synthetic apparatus. These mRNAs contain an oligopyrimidine tract at their 5' transcriptional start site… CONTINUE READING


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