Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.

@article{Verma2002RoleOR,
  title={Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.},
  author={Rati Verma and L. Aravind and Robert S. Oania and W. Hayes McDonald and John R. Yates and Eugene V. Koonin and Raymond J Deshaies},
  journal={Science},
  year={2002},
  volume={298 5593},
  pages={611-5}
}
The 26S proteasome mediates degradation of ubiquitin-conjugated proteins. Although ubiquitin is recycled from proteasome substrates, the molecular basis of deubiquitination at the proteasome and its relation to substrate degradation remain unknown. The Rpn11 subunit of the proteasome lid subcomplex contains a highly conserved Jab1/MPN domain-associated… CONTINUE READING
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