Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton.

@article{Koch1997RoleOR,
  title={Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton.},
  author={Gebhard Koch and Chris Benz and Gudula Schmidt and Claudia Olenik and Klaus Aktories},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 2},
  pages={901-9}
}
The Rho GTPases are involved in actin cytoskeleton organization and signal transduction. They need polyisoprenylation for membrane association and activation. Lovastatin, a hydroxymethylglutaryl coenzyme A inhibitor, prevents isoprene synthesis and thereby lipid modification of the Rho protein carboxy terminus. Because lovastatin causes rounding up of cultured cells, we investigated whether the compound acts on the actin cytoskeleton through Rho proteins. Lovastatin treatment decreased F-actin… CONTINUE READING