Role of Rho kinases in abnormal and normal hematopoiesis.

  title={Role of Rho kinases in abnormal and normal hematopoiesis.},
  author={Raghuveer Singh Mali and Simryn Kapur and Reuben Kapur},
  journal={Current opinion in hematology},
  volume={21 4},
PURPOSE OF REVIEW Rho kinases (ROCKs) are involved in regulating a variety of physiologic functions including cytoskeletal reorganization, migration, adhesion, survival and proliferation. They do so via activating several different downstream substrates such as myosin light chain phosphatase, LIM kinase and ezrin/radixin/moesin proteins. To date, most of the conclusions with regard to the function of ROCKs have involved the use of cell line models, pharmacologic inhibitors and dominant negative… CONTINUE READING