Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.

  title={Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.},
  author={Takeshi Kanda and Koichi Hayashi and Shu Wakino and Koichiro Homma and Kyoko Yoshioka and Kazuhiro Hasegawa and Naoki Sugano and Satoru Tatematsu and Ichiro Takamatsu and Takayuki Mitsuhashi and Takao Saruta},
  volume={45 4},
Angiotensin II enhances the development of atherosclerotic lesion in which cellular proliferation and/or migration are critical steps. Although cyclin-dependent kinase inhibitor, p27, and Rho/Rho-kinase pathway have recently been implicated as factors regulating these events cooperatively, their role in vivo has not been fully elucidated. We evaluated the contribution of p27 and Rho-kinase to angiotensin II-induced vascular injury using p27-deficient mice. Two-week angiotensin II (1500 ng/kg… CONTINUE READING
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  • AR Brasier, A Recinos, MS Eledrisi
  • 2004

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