Role of Rho-kinase and its inhibitors in pulmonary hypertension.

  title={Role of Rho-kinase and its inhibitors in pulmonary hypertension.},
  author={Sy Duong-Quy and Yihua Bei and Zhongmin Liu and Anh Tuan Dinh-Xuan},
  journal={Pharmacology & therapeutics},
  volume={137 3},
Pulmonary hypertension (PH) is an incurable disease with a dreadful survival rate. The disease is characterized by sustained vasoconstriction, progressive vascular remodeling, and irreversible right heart dysfunction. While hypoxic pulmonary vasoconstriction (HPV) is known to be the main pathophysiological factor causing the rise in pulmonary arterial pressure, biological mechanisms leading to HPV and vascular remodeling are multiple and complex and, as yet, incompletely understood. It is… CONTINUE READING
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