Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages.

@article{Marzio2005RoleOR,
  title={Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages.},
  author={Paola Di Marzio and Wei Wei Dai and Giovanni Franchin and Amanda Y. Chan and Marc Symons and Barbara Sherry},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={331 4},
  pages={909-16}
}
The beta-chemokines, MIP-1alpha/CCL3, MIP-1beta/CCL4, and RANTES/CCL5, play a critical role in the selective accumulation and activation of macrophages in inflamed tissues. Herein, we demonstrate that the binding of each of these beta-chemokines to their cognate receptors, CCR1 and CCR5, in either macrophages or in CCR1- or CCR5-transfected CHO cells, induced actin reorganization and the formation of lamellipodia that are characteristic of the activation of the Rho family GTPase, Rac. A… CONTINUE READING