Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells.

@article{Nilius1999RoleOR,
  title={Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells.},
  author={Bernd Nilius and Thomas Voets and Jean Prenen and Holger Barth and Klaus Aktories and Kozo Kaibuchi and Guy Droogmans and Jan Eggermont},
  journal={The Journal of physiology},
  year={1999},
  volume={516 ( Pt 1)},
  pages={67-74}
}
1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing… CONTINUE READING
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