Role of Rho GTPases and their regulators in cancer progression.

@article{Rathinam2011RoleOR,
  title={Role of Rho GTPases and their regulators in cancer progression.},
  author={Rajamani Rathinam and Allison L. Berrier and Suresh K. Alahari},
  journal={Frontiers in bioscience},
  year={2011},
  volume={16},
  pages={
          2561-71
        }
}
Rho family of GTPases is an ubiquitiously expressed and evolutionarily conserved family of GTP binding proteins that regulate actin dynamics and intracellular signaling. Among the Rho family GTPases, three members RhoA, Rac1 and CDC42 have been well characterized. They each play pivotal roles in gene expression, cell proliferation, apoptosis and various cellular functions. They are driven by signaling from RhoGDIs, RhoGEFs, RhoGAPs and cell surface receptors. Abnormalities in Rho GTPase… 
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