Role of Redox Status in Development of Glioblastoma

  title={Role of Redox Status in Development of Glioblastoma},
  author={Alel{\'i} Salazar-Ramiro and Daniela Ram{\'i}rez-Ortega and Ver{\'o}nica P{\'e}rez de la Cruz and Norma Y. H{\'e}rnandez-Pedro and Dinora Gonz{\'a}lez-Esquivel and Julio Sotelo and Benjam{\'i}n Pineda},
  journal={Frontiers in immunology},
Glioblastoma multiforme (GBM) is a highly aggressive neoplasia, prognosis remains dismal, and current therapy is mostly palliative. There are no known risk factors associated with gliomagenesis; however, it is well established that chronic inflammation in brain tissue induces oxidative stress in astrocytes and microglia. High quantities of reactive species of oxygen into the cells can react with several macromolecules, including chromosomal and mitochondrial DNA, leading to damage and… CONTINUE READING
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