Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression.

@article{Hahn2002RoleOR,
  title={Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression.},
  author={Angelika Hahn and Holger Barth and Michaela Kress and Peter R. Mertens and Margarete Goppelt-Struebe},
  journal={The Biochemical journal},
  year={2002},
  volume={362 Pt 1},
  pages={33-40}
}
The role of Rho proteins in lysophosphatidic acid (LPA)-mediated induction of cyclo-oxygenase-2 (Cox-2) was investigated in renal mesangial cells. Previous studies had shown that toxin B, an inhibitor of Rho, Rac and Cdc42, suppressed Cox-2 induction. A role for RhoA in pertussis toxin-sensitive LPA signalling was excluded with C3 transferase from Clostridium limosum, used as the fusion toxin C2IN-C3 (where C2IN is part of the C2I toxin of C. botulinum). Incubation of the cells with C2IN-C3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Lysophosphatidic acid induces endothelial cell death by modulating the redox environment.

American journal of physiology. Regulatory, integrative and comparative physiology • 2007
View 1 Excerpt

Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.

American journal of physiology. Lung cellular and molecular physiology • 2007

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Differential regulation of COX - 2 transcription by Ras - and Rho - family of GTPases

K. Subbaramaiah, J. C. Hart, L. Norton, A. J. Dannenberg
Biochem . Biophys . Res . Commun . • 2000

Similar Papers

Loading similar papers…