Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.

@article{Galbiati2014RoleOR,
  title={Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.},
  author={Valentina Galbiati and Angela Papale and Corrado Lodovico Galli and Marina Marinovich and Emanuela Corsini},
  journal={The Journal of investigative dermatology},
  year={2014},
  volume={134 11},
  pages={2719-2727}
}
Keratinocytes have a key role in all phases of allergic contact dermatitis. We have recently identified the possibility to use IL-18 production for the in vitro identification of contact allergens. The purpose of this study was to characterize the molecular mechanisms underlying allergen-induced IL-18 production, in order to identify the cellular source of reactive oxygen species (ROS) and the danger signals involved. The NCTC2544 cell line was exposed to three contact allergens, namely p… CONTINUE READING
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