Role of RNA structure in regulating pre-mRNA splicing.

  title={Role of RNA structure in regulating pre-mRNA splicing.},
  author={M. Bryan Warf and J Andrew Berglund},
  journal={Trends in biochemical sciences},
  volume={35 3},
Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried out by the spliceosome, along with other auxiliary factors. In general, research in splicing has focused on the sequences within the pre-mRNA, without considering the structures that these sequences might form. We propose that the role of RNA structure deserves more consideration when thinking about splicing mechanisms. RNA structures can inhibit or aid binding of spliceosomal components to the pre-mRNA… CONTINUE READING

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