Role of RNA structure and protein factors in the control of HIV-1 splicing.

@article{Saliou2009RoleOR,
  title={Role of RNA structure and protein factors in the control of HIV-1 splicing.},
  author={Jean-Michel Saliou and Cyril F. Bourgeois and Lilia Ayadi-Ben Mena and Delphine Ropers and Sandrine Jacquenet and Virginie Marchand and James St{\'e}venin and Christiane Branlant},
  journal={Frontiers in bioscience},
  year={2009},
  volume={14},
  pages={
          2714-29
        }
}
Alternative splicing plays a key role in the production of numerous proteins by complex lentiviruses such as HIV-1. The study of HIV-1 RNA splicing has provided useful information not only about the physiology of the virus, but also about the general mechanisms that regulate mammalian pre-mRNA alternative splicing. Like all retroviruses, a fraction of HIV-1 transcripts remains intact to serve as genomic RNA and to code for Gag and Gag-Pol protein precursors. In addition, splicing is important… 
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Chapter 1. Regulation of HIV-1 alternative RNA splicing and its role in virus replication.
Solution structure of the HIV-1 exon splicing silencer 3.
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TLDR
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A review of recent findings related to HIV-1 RNA biosynthesis, especially regulatory mechanisms that control initiation of transcription, capping and polyadenylation, zoom in on the diversity of HIV- 1 derived RNA transcripts, their mode of synthesis and proposed functions in the infected cell.
Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection
TLDR
ONT sequencing is a convenient and reliable strategy that enabled us to grasp the dynamic of the early splicing events modulating the viral RNA landscape in HIV-1 infected cells and highlighted the importance of non-coding exons in viral RNA transcriptome regulation.
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TLDR
Overexpression of SRP14 in resting CD4+ T-cells from patients on ART was sufficient to reverse HIV-1 latency and induce virus production.
Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication
TLDR
Overall, the data indicate complex negative regulation of HIV-1 splicing by RNA elements in various regions of the HIV- 1 genome that enable balanced splicing and viral replication.
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