Role of RNA polymerase III transcription factors in the selection of integration sites by the dictyostelium non-long terminal repeat retrotransposon TRE5-A.

@article{Siol2006RoleOR,
  title={Role of RNA polymerase III transcription factors in the selection of integration sites by the dictyostelium non-long terminal repeat retrotransposon TRE5-A.},
  author={Oliver Siol and Moustapha Boutliliss and Thanh Chung and Gernot Gl{\"o}ckner and Theodor Dingermann and Thomas Winckler},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 22},
  pages={8242-51}
}
In the compact Dictyostelium discoideum genome, non-long terminal repeat (non-LTR) retrotransposons known as TREs avoid accidental integration-mediated gene disruption by targeting the vicinity of tRNA genes. In this study we provide the first evidence that proteins of a non-LTR retrotransposon interact with a target-specific transcription factor to direct its integration. We applied an in vivo selection system that allows for the isolation of natural TRE5-A integrations into a known genomic… CONTINUE READING