Role of RIP1 in physiological enterocyte turnover in mouse small intestine via nonapoptotic death.

@article{Matsuoka2015RoleOR,
  title={Role of RIP1 in physiological enterocyte turnover in mouse small intestine via nonapoptotic death.},
  author={Yosuke Matsuoka and Yoshihide Tsujimoto},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2015},
  volume={20 1},
  pages={
          11-28
        }
}
Enterocyte shedding in the small intestine is often referred as an example of programmed cell death. However, little is known about the underlying mechanisms, although both apoptotic and nonapoptotic cell death have been suggested to play an important role. Here, we show by electron microscope that the majority of cells dying in the mouse small intestine do not display apoptotic characteristics. Chemical biological approach in vivo and in an organ culture showed that necrostatin-1 (Nec-1), an… CONTINUE READING

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