Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation.

@article{Young2002RoleOP,
  title={Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation.},
  author={Christian Young and James Mapes and Jennifer Hanneman and Sheikha S Al-Zarban and Irene Ota},
  journal={Eukaryotic cell},
  year={2002},
  volume={1 6},
  pages={1032-40}
}
Three type 2C Ser/Thr phosphatases (PTCs) are negative regulators of the yeast Saccharomyces cerevisiae high-osmolarity glycerol mitogen-activated protein kinase (MAPK) pathway. Ptc2 and Ptc3 are 75% identical to each other and differ from Ptc1 in having a noncatalytic domain. Previously, we showed that Ptc1 inactivates the pathway by dephosphorylating the Hog1 MAPK; Ptc1 maintains low basal Hog1 activity and dephosphorylates Hog1 during adaptation. Here, we examined the function of Ptc2 and… CONTINUE READING
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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr

  • G. Pearson, F. Robinson, +4 authors M. H. Cobb
  • 2001
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