Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression

  title={Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression},
  author={Eduardo M Rego and Zhugang Wang and Daniela Peruzzi and L Z He and Carlos Cordon-Cardo and Pier Paolo Pandolfi},
  journal={The Journal of Experimental Medicine},
  pages={521 - 530}
The promyelocytic leukemia (PML) gene encodes a putative tumor suppressor gene involved in the control of apoptosis, which is fused to the retinoic acid receptor alpha (RARalpha) gene in the vast majority of acute promyelocytic leukemia (APL) patients as a consequence of chromosomal translocations. The PMLRARalpha oncoprotein is thought to antagonize the function of PML through its ability to heterodimerize with and delocalize PML from the nuclear body. In APL, this may be facilitated by the… CONTINUE READING