Role of Plasmodium berghei cGMP-dependent protein kinase in late liver stage development.

@article{Falae2010RoleOP,
  title={Role of Plasmodium berghei cGMP-dependent protein kinase in late liver stage development.},
  author={Adebola I. Falae and Audrey Combe and Anburaj Amaladoss and Teresa Carvalho and Robert M{\'e}nard and Purnima Bhanot},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 5},
  pages={3282-8}
}
The liver is the first organ infected by Plasmodium sporozoites during malaria infection. In the infected hepatocytes, sporozoites undergo a complex developmental program to eventually generate hepatic merozoites that are released into the bloodstream in membrane-bound vesicles termed merosomes. Parasites blocked at an early developmental stage inside hepatocytes elicit a protective host immune response, making them attractive targets in the effort to develop a pre-erythrocytic stage vaccine… CONTINUE READING