Role of Piperine as an Effective Bioenhancer in Drug Absorption

@article{Db2018RoleOP,
  title={Role of Piperine as an Effective Bioenhancer in Drug Absorption},
  author={Mhaske Db and Sunil P. Sreedharan and Mahadik Kr},
  journal={Pharmaceutica Analytica Acta},
  year={2018},
  volume={09},
  pages={1-4}
}
Bioenhancers can be defined as chemical entities, which when mixed with drugs promote and augment their bioavailability without showing any synergistic effect with the drug. The factors like toxicity, cost, poor bioavailability and long term administration of drugs give rise to the need of bioenhancers which help overcome most of these problems. Piper species produce a pungent alkaloid named Piperine or 1-peperoyl piperidine. Piperine increases permeability at the site of absorption by… 

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References

SHOWING 1-10 OF 55 REFERENCES

Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives

TLDR
Better understanding the clinical relevance of p Piperine-drug interactions based on long-term assessments will provide a strong basis for the feasibility and applicability of piperine as a bioenhancer or a health-promoting agent.

Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats.

Investigation of Need of Natural Bioenhancer for a Metabolism Susceptible Drug—Raloxifene, in a Designed Self-Emulsifying Drug Delivery System

TLDR
No additional improvement in permeability and bioavailability was offered by inclusion of piperine and quercetin (bioenhancers) in the self-emulsifying drug delivery system of RLX.

Enhancing the bioavailability of resveratrol by combining it with piperine.

TLDR
Piperine significantly improves the in vivo bioavailability of resveratrol through inhibiting its glucuronidation, thereby slowing its elimination and further detailed research is needed to study the mechanism of improved bioavailability via its combination with piperine.

Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

TLDR
It is demonstrated that piperine is a nonspecific inhibitor of drug metabolism which shows little discrimination between different cytochrome P-450 forms.

Influence of Co-Administration of Piperine on Pharmacokinetic Profile of Gatifloxacin in Layer Birds

TLDR
It is revealed that piperine has significant effect on the pharmacokinetics of the Gatifloxacin, a fourth generation, 8-methoxy fluoroquinolone.

Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics.

TLDR
Piperine (10 mg/kg) significantly increased the dose-dependent antinociceptive activity of ibuprofen evaluated by both acetic acid writhing and formalin test, when it was administered with ib uprofen.

Piperine in food: Interference in the pharmacokinetics of phenytoin

TLDR
Intravenous phenytoin in the oral piperine-treated rat group showed a significant alteration in the elimination phase indicating its metabolic blockade, and the significance of this finding in epileptic patients maintained on pheny toin therapy requires further investigation.

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

TLDR
It is shown that piperine inhibits both the drug transporter P-glycoprotein and the major drug-metabolizing enzyme CYP3A4.
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