Role of Phosphodiesterases in Huntington's Disease.

Abstract

Huntington's disease (HD) is an autosomal-dominant rare inherited neurodegenerative disease characterized by a wide variety of symptoms encompassing movement, cognition and behaviour. The cause of the disease is a genetic mutation in the huntingtin protein. The mutation leads to an unstable CAG expansion, translated into a polyglutamine domain within the… (More)
DOI: 10.1007/978-3-319-58811-7_11

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