Role of Phosphate Groups in Inhibition of Calcium Oxalate Crystal Growth by Osteopontin

@article{Hunter2008RoleOP,
  title={Role of Phosphate Groups in Inhibition of Calcium Oxalate Crystal Growth by Osteopontin},
  author={Graeme K. Hunter and Bernd Grohe and S Vetter Jeffrey and Jason O’Young and Esben Skipper S{\o}rensen and Harvey A Goldberg},
  journal={Cells Tissues Organs},
  year={2008},
  volume={189},
  pages={44 - 50}
}
Osteopontin (OPN) inhibits the growth of calcium oxalate monohydrate (COM) and other crystal phases in a phosphorylation-dependent manner. In the present study, the role of OPN phosphate groups in adsorption to, incorporation into and inhibition of COM crystals was studied by comparing OPN isoforms differing in phosphorylation. OPN isoforms purified from rat bone (bOPN), which contains 10 phosphates, and cow milk (mOPN), which contains 25 phosphates, were compared with rat recombinant OPN (rOPN… CONTINUE READING

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