Role of PPARgamma in macrophage biology and atherosclerosis.

  title={Role of PPARgamma in macrophage biology and atherosclerosis.},
  author={Lina Zhang and Ajay Chawla},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={15 10},
Macrophages carry out key functions by defending a host from microbial invaders and by clearing endogenous cellular debris. Molecules that are essential for the recognition, phagocytosis and clearance of pathogens also mediate the uptake and degradation of pathogenic lipoproteins. During atherogenesis, for example, scavenging trapped lipoproteins leads to the formation of foam cells and subsequently the activation of these lipid-laden macrophages. Although they are initially clinically silent… CONTINUE READING