Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.

@article{Lapinskas2005RoleOP,
  title={Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.},
  author={Paula J. Lapinskas and Sherri Brown and Lisa M. Leesnitzer and Steven Blanchard and Cyndi Swanson and Russell C. Cattley and J Christopher Corton},
  journal={Toxicology},
  year={2005},
  volume={207 1},
  pages={149-63}
}
Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP). PP include chemicals that activate different subtypes of the peroxisome proliferator-activated receptor (PPAR) family. The ability of phthalate esters and their metabolites to activate responses through different PPAR subtypes is not fully characterized. We investigated the ability of two phthalate esters di-(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) and selected metabolites to… CONTINUE READING