Role of PP2Cα in cell growth, in radio- and chemosensitivity, and in tumorigenicity

@article{Lammers2007RoleOP,
  title={Role of PP2Cα in cell growth, in radio- and chemosensitivity, and in tumorigenicity},
  author={Twan Lammers and P. Peschke and Volker Ehemann and J{\"u}rgen Debus and Boris Slobodin and Sara Lavi and Peter E Huber},
  journal={Molecular Cancer},
  year={2007},
  volume={6},
  pages={65 - 65}
}
PP2Cα is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFβ-, cyclin-dependent kinase- and apoptosis-signaling. To investigate the role of PP2Cα in cell growth and in radio- and chemosensitivity, wild type and PP2Cα siRNA-expressing MCF7 cells were subjected to several different viability and cell cycle analyses, both under basal conditions and upon treatment with radio- and chemotherapy. By comparing the… CONTINUE READING

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